Based on the analysis of the effectiveness evaluation requirements of the cyberspace information defense combat command, an evaluation index system, evaluation model and evaluation framework are constructed according to the construction principles of the index system and the influencing factors. In traditional command effectiveness evaluation method of the contestant personnel evaluation, the problems such as randomicity and subjective uncertainty inevitably occur. Based on the fuzzy neural network, a network defense battle command effectiveness evaluation model of space information is proposed. The advantages of the fuzzy neural network such as self-learning, adaptive and strong fault tolerance are used to optimize the connection weights and fuzzy parameters of the network, and weaken the human factors in the effectiveness evaluation. The feasibility of the model is verified through the simulation experiment, which provides guidance and reference for the construction of cyberspace information defense combat command system.